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159161,163,178 In these four studies, a significantly increased risk of developing vitamin B 12 depletion as a result use of acid-lowering medication was identified and data from the two studies evaluating duration of treatment supported the general assumption that long-term use of these drugs is associated with an elevated risk of deficiency of this vitamin, but the results were not conclusive

Retrieved from Mayo Clinic

Additionally, activation of the trigeminal nerve (by the pre-monitory and aura phase) further sensitizes the pain receptors in the brain

Overall, there is very little risk in having a blood test usually only mild bruising or pain that goes away quickly

STEP 3 Investigators